Mouse CRTAM Recombinant Protein (C-His) (MF645011)

Name: Mouse CRTAM Recombinant Protein (C-His)
Brand: abinScience
SKU: MF645011
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	MF645011
Description	Recombinant Mouse CRTAM Protein, C-His (MF645011) expressed in Mammalian Cells, spanning Ala17-Gly289. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	Q149L7
Protein length	Ala17-Gly289
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	32.93 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD355, CRTAM, Class-I MHC-restricted T-cell-associated molecule, Cytotoxic and regulatory T-cell molecule
Background	Cytotoxic and regulatory T-cell molecule is a ~43 kDa protein. Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. 1. Boles, KS. et al. (2005) Blood 106, 779-86. PMID: 15811952 2. Yeh, JH. et al. (2008) Cell 132, 846-59. PMID: 18329370 3. Takeuchi, A. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 4220-8. PMID: 19752223 4. Cortez, VS. et al. (2014) The Journal of experimental medicine 211, 623-33. PMID: 24687959
Note	For research use only

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Datasheet

Mouse CRTAM Recombinant Protein (C-His).pdf

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Mouse CRTAM Recombinant Protein (C-His) (MF645011)

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