Mouse KPNA2 Recombinant Protein (N-His) (MW788012)

Name: Mouse KPNA2 Recombinant Protein (N-His)
Brand: abinScience
SKU: MW788012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MW788012
Description	Recombinant Mouse KPNA2 Protein, N-His (MW788012) expressed in E. coli, spanning Gln71-Ser497. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P52293
Protein length	Gln71-Ser497
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	48.52 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Importin subunit alpha-1, KPNA2, Karyopherin subunit alpha-2, RAG cohort protein 1, RCH1, SRP1, SRP1-alpha
Background	Importin subunit alpha-1 is a ~57 kDa protein. Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 1. Lott, K. et al. (2011) The Journal of biological chemistry 286, 28160-9. PMID: 21690087
Note	For research use only

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Datasheet

Mouse KPNA2 Recombinant Protein (N-His).pdf

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Mouse KPNA2 Recombinant Protein (N-His) (MW788012)

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