Mouse TRPM4/LTRPC4 Recombinant Protein (N-His) (MP790012)

Name: Mouse TRPM4/LTRPC4 Recombinant Protein (N-His)
Brand: abinScience
SKU: MP790012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MP790012
Description	Recombinant Mouse TRPM4/LTRPC4 Protein, N-His (MP790012) expressed in E. coli, spanning Thr73-Ile270. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q7TN37
Protein length	Thr73-Ile270
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	23.92 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Calcium-activated non-selective cation channel 1, LTRPC4, LTrpC-4, LTrpC4, Long transient receptor potential channel 4, Melastatin-4, TRPM4, Transient receptor potential cation channel subfamily M member 4, hTRPM4
Background	Transient receptor potential cation channel subfamily M member 4 is a ~135 kDa protein. Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. 1. Demion, M. et al. (2007) Cardiovascular research 73, 531-8. PMID: 17188667 2. Guo, J. et al. (2017) Nature 552, 205-209. PMID: 29211714 3. Barbet, G. et al. (2008) Nature immunology 9, 1148-56. PMID: 18758465
Note	For research use only

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Datasheet

Mouse TRPM4/LTRPC4 Recombinant Protein (N-His).pdf

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Mouse TRPM4/LTRPC4 Recombinant Protein (N-His) (MP790012)

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