Mouse ZC3H12A Recombinant Protein (N-His) (MS805012)

Name: Mouse ZC3H12A Recombinant Protein (N-His)
Brand: abinScience
SKU: MS805012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MS805012
Description	Recombinant Mouse ZC3H12A Protein, N-His (MS805012) expressed in E. coli. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q5D1E7
Protein length	Arg136-Lys294(Phe234Tyr)
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	20.85 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:3.1.-.-, Endoribonuclease ZC3H12A, MCP-induced protein 1, MCPIP, MCPIP-1, MCPIP1, Monocyte chemotactic protein-induced protein 1, Reg1, Regnase-1, ZC3H12A, Zinc finger CCCH domain-containing protein 12A
Background	Endoribonuclease ZC3H12A is a ~65 kDa protein. Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. 1. Mino, T. et al. (2015) Cell 161, 1058-1073. PMID: 26000482 2. Matsushita, K. et al. (2009) Nature 458, 1185-90. PMID: 19322177 3. Liang, J. et al. (2010) The Journal of experimental medicine 207, 2959-73. PMID: 21115689 4. Li, M. et al. (2012) PloS one 7, e49841. PMID: 23185455 5. Uehata, T. et al. (2013) Cell 153, 1036-49. PMID: 23706741 10. Huang, S. et al. (2015) The Journal of biological chemistry 290, 20782-20792. PMID: 26134560
Note	For research use only

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Mouse ZC3H12A Recombinant Protein (N-His).pdf

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Mouse ZC3H12A Recombinant Protein (N-His) (MS805012)

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