Anti-Human PD-L1 & 4-1BB/TNFRSF9/CD137 Bispecific Reference Antibody (Acasunlimab, RUO) (HV974136)

Name: Anti-Human PD-L1 & 4-1BB/TNFRSF9/CD137 Bispecific Reference Antibody (Acasunlimab, RUO)
Brand: abinScience
SKU: HV974136
Price: 400 USD
Availability: InStock

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SDS

Overview

Catalog No.	HV974136
Description	Acasunlimab (HV974136) is a research-grade recombinant antibody targeting CD1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG1;Lambda;Kappa
Clone ID	Acasunlimab
Expression system	Mammalian cells
Nature	Recombinant
Target	B7 homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1, 4-1BB ligand receptor, CD137, CDw137, ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NZQ7 & Q07011
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Bispecific, BNT-311, DuoBody-PD-L1x4-1BB, GEN-1046, 2253937-12-9
Background	Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects CD137/TNFRSF9/4-1BB in indirect ELISAs.
Bioactivity

Detects CD274/PD-L1/B7-H1 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Acasunlimab.

References

Datasheet

Anti-Human PD-L1 & 4-1BB/TNFRSF9/CD137 Bispecific Reference Antibody (Acasunlimab, RUO).pdf

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Formula

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Recombinant Proteins

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Assay Kits

Anti-Human PD-L1 & 4-1BB/TNFRSF9/CD137 Bispecific Reference Antibody (Acasunlimab, RUO) (HV974136)

Overview

Images

References

Datasheet

SDS