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Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO) (HY546046)

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Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO)

Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO)

Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO)

Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO)

Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO)

Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO)

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Spec:

100ug
1mg

Number:

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HY546046
Description	Altumomab (HY546046) is a research-grade recombinant antibody targeting CD66. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Mouse
Isotype	IgG1-nd
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Meconium antigen 100, CEACAM5, CEA, CD66e, Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P06731
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	HYBRI-CEAKER
Background	Cell adhesion molecule CEACAM5 (CD66e) is a ~76 kDa protein. Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells. 1. Taheri, M. et al. (2000) The Journal of biological chemistry 275, 26935-43. PMID: 10864933 2. Ordoñez, C. et al. (2000) Cancer research 60, 3419-24. PMID: 10910050 3. Oikawa, S. et al. (1989) Biochemical and biophysical research communications 164, 39-45. PMID: 2803308
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects recombinant human CD66e/CEA/CEACAM5 (Cat No.: HY546011) in indirect ELISA.
SDS-PAGE

SDS-PAGE for Research Grade Altumomab.
Western blot

Western blot analysis was performed using anti-CD66e/CEA/CEACAM5 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD66e/CEA/CEACAM5 (Catalog No: HY546011)
Lane 2: negative control

References

Datasheet

Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO).pdf

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Anti-Human CEACAM-5/CD66e Reference Antibody (Altumomab, RUO)