Anti-Human MMP-9 Reference Antibody (Andecaliximab, RUO) (HB945016)

Name: Anti-Human MMP-9 Reference Antibody (Andecaliximab, RUO)
Brand: abinScience
SKU: HB945016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HB945016
Description	Andecaliximab (HB945016) is a research-grade recombinant antibody targeting Matrix metalloproteinase-9. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Chimeric
Isotype	IgG4-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Matrix metalloproteinase-9, CLG4B, GELB, 92 kDa type IV collagenase, 92 kDa gelatinase, Gelatinase B, MMP9, MMP-9
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P14780
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GS-5745, 1518996-49-0
Background	Matrix metalloproteinase-9 (MMP9) is a ~78 kDa protein. Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-\|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. 1. Takino, T. et al. (2003) Oncogene 22, 4617-26. PMID: 12879005 2. Tschesche, H. et al. (1992) Matrix (Stuttgart, Germany). Supplement 1, 245-55. PMID: 1480034 3. Wilhelm, SM. et al. (1989) The Journal of biological chemistry 264, 17213-21. PMID: 2551898 4. Jeon, S. et al. (2020) Circulation 142, 1736-1751. PMID: 32883094
Note	For research use only. Not suitable for clinical or therapeutic use.

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SEC-HPLC

SEC-HPLC detection for Research Grade Andecaliximab.
Bioactivity

Detects MMP9 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Andecaliximab.

References

Datasheet

Anti-Human MMP-9 Reference Antibody (Andecaliximab, RUO).pdf

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Recombinant Proteins

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Anti-Human MMP-9 Reference Antibody (Andecaliximab, RUO) (HB945016)

Overview

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References

Datasheet

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