Anti-ChoPPhosphorylcholine Reference Antibody (ATH3G10, RUO) (HP719016)

Name: Anti-ChoPPhosphorylcholine Reference Antibody (ATH3G10, RUO)
Brand: abinScience
SKU: HP719016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HP719016
Species reactivity	General
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	ATH3G10
Biological activity	Phosphorylcholine is a component of drug delivery micelles, which improves the efficiency of cellular internalization and increases the cytotoxicity of cytotoxins carried in micelles in HeLa cells [2]. Phosphorylcholine (200-600 umol/kg; ip; single dose) activates nicotinic and muscarinic cholinergic neurotransmission, stimulates the activation of α2-adrenergic receptors, and increases plasma glucagon and choline concentrations, thereby stimulating peripheral autonomic nervous system activity [3]. Phosphorylcholine (2 ug; ip; once every two weeks for 4 months) induces the production of anti-PC and anti-oxLDL antibodies, increases mature B cells in the spleen, and reduces atherosclerotic lesions in the aortic root in mouse models [4].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Phosphocholine, Phosphorylcholine, ChoP
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	ChEBI: 18132, CAS: 107-73-3
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ATH3G10, ATH3G10, ATH-3G10
References	1. Harnett W, et al. Phosphorylcholine: friend or foe of the immune system? Immunol Today. 1999 Mar;20(3):125-9. [HP719016] 2. Tu S, et al., Enhancement of cellular uptake and antitumor efficiencies of micelles with phosphorylcholine. Macromol Biosci. 2011 Oct 10;11(10):1416-25. [HP719016] 3. Cansev M, et al., Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system. Eur J Pharmacol. 2008 Jul 28;589(1-3):315-22. [HP719016] 4. Caligiuri G, et al., Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol. 2007 Aug 7;50(6):540-6. View More [HP719016]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-ChoPPhosphorylcholine Antibody (ATH3G10)

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Anti-ChoPPhosphorylcholine Reference Antibody (ATH3G10, RUO).pdf

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Anti-ChoPPhosphorylcholine Reference Antibody (ATH3G10, RUO) (HP719016)

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