Anti-Human Flt-3/Flk-2 ligand Reference Antibody (AMG 329, RUO) (HW688026)

Name: Anti-Human Flt-3/Flk-2 ligand Reference Antibody (AMG 329, RUO)
Brand: abinScience
SKU: HW688026
Price: 370 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HW688026

Description

Research Grade Anti-FLT3 ligand Antibody (AMG 329) [AMG 329] (HW688026) is a human monoclonal antibody detecting Receptor-type tyrosine-protein kinase FLT3 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.

Highlights

●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Host species

Human

Isotype

IgG1, lambda

Clone ID

AMG 329

Clonality

Monoclonal

Target

Receptor-type tyrosine-protein kinase FLT3, EC:2.7.10.1, FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1, CD135, FLT3, CD135, FLK2, STK1

Endotoxin level

<1 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P36888

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

MEDI1116,VIB-1116, HZN-1116, VIB 1116, VIB1116, HZN 1116, HZN1116

Background

Receptor-type tyrosine-protein kinase FLT3 (FLT3 ligand) is a ~112 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B.

Note

For research use only.

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