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Anti-HIV1 gp120/Glycoprotein 120 Reference Antibody (mD1.22, RUO) (VK617106)

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Overview

Catalog No.	VK617106
Description	Anti-HIV1 gp120/Glycoprotein 120 Antibody (mD1.22) (VK617106) is a research-grade recombinant antibody targeting CD4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human immunodeficiency virus 1 (HIV-1)
Applications	ELISA, Functional assay, Research in vivo
Isotype	Fusion - [CD4 (LFA3, lymphocyte function associated antigen 3)]2 - IGHG1 Fc (Fragment constant)
Clone ID	mD1.22
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, CD4
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P01730
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	T-cell surface glycoprotein CD4 (gp120/Glycoprotein 120) is a ~51 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Anti-HIV1 gp120/Glycoprotein 120 Reference Antibody (mD1.22, RUO).pdf

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Anti-HIV1 gp120/Glycoprotein 120 Reference Antibody (mD1.22, RUO)