Anti-HRSV Pre-Fusion Glycoprotein Reference Antibody (RSM01, RUO) (VK421266)

Name: Anti-HRSV Pre-Fusion Glycoprotein Reference Antibody (RSM01, RUO)
Brand: abinScience
SKU: VK421266
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	VK421266
Species reactivity	Human respiratory syncytial virus A (HRSV-A)
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG1
Clone ID	RSM01
Biological activity	RSM-01 tightly binds to the highly conserved Ø site on the Pre-F protein, blocks viral conformational changes, inhibits viral fusion with host cell membranes, and prevents viral entry into cells. It exhibits ultra-high neutralizing activity against both RSV subtype A and subtype B [1].
Target	F, F1, F2, Fusion glycoprotein F0, Fusion glycoprotein F1, Fusion glycoprotein F2, Intervening segment, Pep27, Peptide 27, p27
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P03420, P11209, 12568, O36634, P13843
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	RSM-01, RSM01, RSM01
Background	Fusion glycoprotein F0 (Prefusion/Pre-F) is a ~63 kDa protein. Inactive precursor that is cleaved at two sites by a furin-like protease to give rise to the mature F1 and F2 fusion glycoproteins.
References	1. Scotta MC, et al. Current strategies and perspectives for active and passive immunization against Respiratory Syncytial Virus in childhood. J Pediatr (Rio J). 2023;99 Suppl 1(Suppl 1):S4-S11. [VK421266]
Note	For research use only. Not suitable for clinical or therapeutic use.