Anti-Human Activin Receptor IIB Reference Antibody (KER-012, RUO) (HC570026)

Name: Anti-Human Activin Receptor IIB Reference Antibody (KER-012, RUO)
Brand: abinScience
SKU: HC570026
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HC570026
Description	Anti-Human ACVR2B Antibody (KER-012) (HC570026) is a research-grade recombinant antibody targeting ACTR-IIB. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Isotype	Fusion-[human ACTR-IIB]2-Fc (Fragment constant)
Clone ID	KER-012
Expression system	Mammalian cells
Clonality	Monoclonal
Target	ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q13705
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	KER012, RKER-012, RKER012
Background	Activin receptor type-2B (ACVR2B) is a ~57 kDa protein. Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals.
Note	For research use only. Not suitable for clinical or therapeutic use.