Anti-Human CTLA-4 Reference Antibody (ADU-1604, RUO) (HB651126)

Name: Anti-Human CTLA-4 Reference Antibody (ADU-1604, RUO)
Brand: abinScience
SKU: HB651126
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HB651126
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	ADU-1604
Biological activity	ADU-1604 (30 mg/kg, i.v., once a week for 5 weeks) is well tolerated in cynomolgus monkeys [2]. ADU-1604 demonstrates comparable anti-tumor efficacy to a reference antibody upon systemic administration and following intertumoral injection in humanized non-small cell lung cancer (NSCLC) PDX models [2].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	CD152, Cytotoxic T-lymphocyte protein 4, CTLA-4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P16410
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ADU-1604, ADU1604, ADU1604
Background	Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy). 1. Schwartz, JC. et al. (2001) Nature 410, 604-8. PMID: 11279501 2. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502 3. Teft, WA. et al. (2006) Annual review of immunology 24, 65-97. PMID: 16551244 4. Linsley, PS. et al. (1991) The Journal of experimental medicine 174, 561-9. PMID: 1714933 5. Zheng, Y. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1683-91. PMID: 18641304 6. Ramagopal, UA. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E4223-E4232. PMID: 28484017
References	1. Velasco G D, et al. ADU-1604, a novel CTLA-4 blocking antibody, to modulate pharmacodynamic markers in patients with PD1 relapse/refractory melanoma. 2024. [HB651126] 2. Maaike Hendriks, et al. Abstract 1702: Assessment of pharmacology and toxicology of anti-CTLA-4 antibody (ADU-1604) in non-human primates and evaluation of local anti-CTLA-4 application. 2018. Volume 78, issue 13 [HB651126]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human CD152/CTLA4 (ADU-1604)

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Datasheet

Anti-Human CTLA-4 Reference Antibody (ADU-1604, RUO).pdf

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Anti-Human CTLA-4 Reference Antibody (ADU-1604, RUO) (HB651126)

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