Anti-Human Siglec-2/CD226/DNAM-1 Reference Antibody (lilly01, RUO) (HS737016)

Name: Anti-Human Siglec-2/CD226/DNAM-1 Reference Antibody (lilly01, RUO)
Brand: abinScience
SKU: HS737016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HS737016
Description	Anti-Human CD226/DNAM-1 Antibody (lilly01) (HS737016) is a research-grade recombinant antibody targeting CD226. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG2
Clone ID	lilly01
Expression system	Mammalian cells
Clonality	Monoclonal
Target	DNAX accessory molecule 1, DNAM-1, DNAM1, CD226 antigen, CD226
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q15762
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	CD226 antigen (DNAM-1) is a ~38 kDa protein. Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes. 1. Shibuya, A. et al. (1996) Immunity 4, 573-81. PMID: 8673704 2. Shibuya, A. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 1671-6. PMID: 9712030 3. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705 4. Deuss, FA. et al. (2019) The Journal of biological chemistry 294, 12534-12546. PMID: 31253644 5. Wang, H. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 988-996. PMID: 30591568
Note	For research use only. Not suitable for clinical or therapeutic use.