Anti-Human ST6GAL1/CD75 Reference Antibody (EBU-141 Tetra, RUO) (HB145016)

Name: Anti-Human ST6GAL1/CD75 Reference Antibody (EBU-141 Tetra, RUO)
Brand: abinScience
SKU: HB145016
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HB145016
Description	Anti-Human CD75/ST6GAL1 (EBU-141 Tetra) (HB145016) is a research-grade recombinant antibody targeting CD75. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	EBU-141 Tetra
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Alpha 2, 6-ST 1, B-cell antigen CD75, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 1, SIAT1, Sialyltransferase 1, ST6GAL1, ST6Gal I, Beta-galactoside alpha-2, 6-sialyltransferase 1, ST6GalI
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P15907
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EBU-141Tetra, EBU141Tetra, EBU141Tetra
Background	Beta-galactoside alpha-2,6-sialyltransferase 1 (CD75/ST6GAL1) is a ~46 kDa protein. Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. In B lymphocytes, generates neuraminidase-sensitive lymphocyte cell-surface differentiation antigens, such as CDw75, HB-6 and CD76. Sialylates complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs confering anti-inflammatory effector functions. Preferentially monosialylates the alpha(1->3) mannose antenna of Fc glycoforms with subsequent disialylation occurring at a much slower rate. 1. Bast, BJ. et al. (1992) The Journal of cell biology 116, 423-35. PMID: 1730763
Note	For research use only. Not suitable for clinical or therapeutic use.