Anti-Human Connexin 43/GJA1 Reference Antibody (ALMB-0168, RUO) (HB620016)

Name: Anti-Human Connexin 43/GJA1 Reference Antibody (ALMB-0168, RUO)
Brand: abinScience
SKU: HB620016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HB620016
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	ALMB-0168
Expression system	Mammalian cells
Clonality	Monoclonal
Target	GJAL, Connexin-43, GJA1, Cx43, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P17302
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ALMB-0168, ALMB0168, ALMB0168
Background	Gap junction alpha-1 protein (CX43/GJA1) is a ~43 kDa protein. Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (Probable). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in the conductive system of ventricular myocardium and heart morphogenesis. 1. Ablasser, A. et al. (2013) Nature 503, 530-4. PMID: 24077100 2. Pépin, G. et al. (2020) mBio 11. PMID: 31992625 3. Huai, W. et al. (2025) Immunity 58, 797-810.e6. PMID: 40010341
References	1. Xianbiao Xie, et al. Durable disease control following treatment with ALMB-0168, a novel Cx43 hemichannel agonist monoclonal antibody, in femoral osteosarcoma with lung metastases after chemotherapy failure: a case report. Antibody Therapeutics, 2026, tbag007 [HB620016]
Note	For research use only. Not suitable for clinical or therapeutic use.