Anti-Human DAG1/Dystroglycan Reference Antibody (DAG-6F4, RUO) (HC564016)

Name: Anti-Human DAG1/Dystroglycan Reference Antibody (DAG-6F4, RUO)
Brand: abinScience
SKU: HC564016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HC564016
Description	Anti-Human DAG1/Dystroglycan (DAG-6F4) (HC564016) is a research-grade recombinant antibody targeting Dystrophin-associated glycoprotein 1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG
Clone ID	DAG-6F4
Expression system	Mammalian cells
Target	Dystrophin-associated glycoprotein 1, DAG1, Alpha-DG, Dystroglycan, Beta-DG
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q14118
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DAG-6F4, DAG6F4, DAG6F4
Background	Dystroglycan 1 (DAG1) is a ~97 kDa protein. The dystroglycan complex is involved in a number of signaling events and processes including laminin deposition and extracellular matrix assembly, acetylcholine receptor clustering, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, epithelial polarization, and epithelium branching morphogenesis. Required for the formation of photoreceptor ribbon synapses, and long-term maintenance of inhibitory synapses in cerebellar Purkinje cells. Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation. 1. Eldridge, S. et al. (2016) Annals of the rheumatic diseases 75, 1228-35. PMID: 26290588
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human DAG1/Dystroglycan (DAG-6F4)

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Anti-Human DAG1/Dystroglycan Reference Antibody (DAG-6F4, RUO).pdf

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Anti-Human DAG1/Dystroglycan Reference Antibody (DAG-6F4, RUO) (HC564016)

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