Anti-Human EphA4 Reference Antibody (MEDI-542, RUO) (HX148026)

Name: Anti-Human EphA4 Reference Antibody (MEDI-542, RUO)
Brand: abinScience
SKU: HX148026
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HX148026
Description	Anti-Human EPHA4 Antibody (MEDI-542) (HX148026) is a research-grade recombinant antibody targeting Tyrosine-protein kinase receptor SEK. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG2a, kappa
Clone ID	MEDI-542
Expression system	Mammalian cells
Target	Tyrosine-protein kinase receptor SEK, Tyrosine-protein kinase TYRO1, Ephrin type-A receptor 4, TYRO1, EPHA4, EPH-like kinase 8, hEK8, SEK, EK8, HEK8
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P54764
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MEDI-542, MEDI542, MEDI542
Background	Ephrin type-A receptor 4 (EPHA4) is a ~109 kDa protein. Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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SDS-PAGE for Research Grade Anti-Human EPHA4 Antibody (MEDI-542)

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Anti-Human EphA4 Reference Antibody (MEDI-542, RUO).pdf

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Anti-Human EphA4 Reference Antibody (MEDI-542, RUO) (HX148026)

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