Anti-Human F2RL1/PAR-2 Reference Antibody (PAR650097, RUO) (HX041016)

Name: Anti-Human F2RL1/PAR-2 Reference Antibody (PAR650097, RUO)
Brand: abinScience
SKU: HX041016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HX041016
Description	Anti-Human F2RL1/PAR-2 Antibody (PAR650097) (HX041016) is a research-grade recombinant antibody targeting GPR11. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	PAR650097
Expression system	Mammalian cells
Target	GPR11, Thrombin receptor-like 1, G-protein coupled receptor 11, F2RL1, PAR-2, Coagulation factor II receptor-like 1, Proteinase-activated receptor 2, PAR2
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P55085
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	PAR650097, PAR650097, PAR-650097
Background	Proteinase-activated receptor 2 (F2RL1/PAR-2) is a ~44 kDa protein. Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. 1. Cheng, RKY. et al. (2017) Nature 545, 112-115. PMID: 28445455 2. Kuckleburg, CJ. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 275-84. PMID: 23202369 3. Cocks, TM. et al. (1999) Nature 398, 156-60. PMID: 10086357 4. Botham, A. et al. (2011) The Biochemical journal 438, 359-67. PMID: 21627585 5. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427
Note	For research use only. Not suitable for clinical or therapeutic use.