Anti-Human VEGFR3/Flt-4 Reference Antibody (LY3022856, RUO) (HW579016)

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100ug
1mg

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Overview

Catalog No.	HW579016
Description	Anti-Human FLT4 (LY3022856) (HW579016) is a research-grade recombinant antibody targeting Vascular endothelial growth factor receptor 3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Clone ID	LY3022856
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, FLT-4, VEGFR3, FLT4
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P35916
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	LY3022856
Background	Vascular endothelial growth factor receptor 3 (FLT4/VEGFR3) is a ~152 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human FLT4 (LY3022856).

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Datasheet

Anti-Human VEGFR3/Flt-4 Reference Antibody (LY3022856, RUO).pdf

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Anti-Human VEGFR3/Flt-4 Reference Antibody (LY3022856, RUO) (HW579016)

Overview

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References

Datasheet

SDS

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