Anti-Human αVβ6 Reference Antibody (STX-100, RUO) (HY065046)

Name: Anti-Human αVβ6 Reference Antibody (STX-100, RUO)
Brand: abinScience
SKU: HY065046
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HY065046
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Clone ID	STX-100
Biological activity	STX-100 (1 h pretreatment) exhibits minimal inhibitory effects on TGF-β1-induced morphological and nuclear changes in A549 cells [3]. STX-100 (1 h pretreatment) does not substantially alter actin cytoskeletal organization in A549 cells and does not prevent TGF-β1-associated changes in actin distribution [3]. STX-100 (1 h pretreatment) has limited inhibitory effects on TGF-β1-induced morphological and nuclear changes in MCF10A cells [3]. STX-100 (1 h pretreatment) does not reverse TGF-β1-induced changes in cell organization, cell-cell adhesion, nuclear morphology, or extracellular matrix structure in MCF10A cells [3]. STX-100 (1 h pretreatment) does not substantially alter TGF-β1-driven changes in fibronectin fibril organization in MCF10A cells [3]. STX-100 (3 mg/kg; s.c.; weekly; 8 weeks) promotes acute renal allograft rejection in rhesus macaques [2].
Expression system	Mammalian cells
Tested applications	FCM
Target	MSK8, VNRA, Vitronectin receptor, Integrin alpha-V, Vitronectin receptor subunit alpha, CD51, ITGAV, VTNR, ITGB6, Integrin beta-6
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P06756 & P18564
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Bispecific, STX-100, STX100, STX100
References	1. Crunkhorn S. Deal watch: Biogen acquires Stromedix to pursue novel fibrosis therapy. Nat Rev Drug Discov. 2012 Mar 30;11(4):260. [HY065046] 2. Lo DJ, et al. Inhibition of αvβ6 promotes acute renal allograft rejection in nonhuman primates. Am J Transplant. 2013;13(12):3085-3093. [HY065046] 3. Wesam Elhawabri. REGULATION OF TGF-β1–INDUCED EPITHELIAL–MESENCHYMAL TRANSITION BY INTEGRIN INHIBITION. [HY065046] 4. Sylvers PH, et al. Mitigation of harmful algal blooms caused by Alexandrium catenella and reduction in saxitoxin accumulation in bivalves using cultivable seaweeds. Harmful Algae. 2021;105:102056. [HY065046] 5. Raghu G, et al. Randomized Phase IIa Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1166-1168. View More [HY065046]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human Integrin AVB6 (ITGAV & ITGB6) Antibody (STX-100)
Flow cytometry

Flow-cytometry using anti-human ITGB6 antibody. HT29 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ITGB6 monoclonal antibody (Catalog HY065046, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet

Anti-Human αVβ6 Reference Antibody (STX-100, RUO).pdf

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Anti-Human αVβ6 Reference Antibody (STX-100, RUO) (HY065046)

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