Anti-Human Ly-6A/E Reference Antibody (RG 7841, RUO) (HS714016)

Name: Anti-Human Ly-6A/E Reference Antibody (RG 7841, RUO)
Brand: abinScience
SKU: HS714016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HS714016
Description	Anti-Human LY6E/SCA-2 (RG 7841) (HS714016) is a research-grade recombinant antibody targeting SCA-2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	RG 7841
Expression system	Mammalian cells
Clonality	Monoclonal
Target	SCA-2, TSA-1, 9804, Retinoic acid-induced gene E protein, TSA1, Lymphocyte antigen 6E, Ly-6E, Stem cell antigen 2, Thymic shared antigen 1, SCA2, RIGE, LY6E, RIG-E
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q16553
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	RG-7841, RG7841, RG7841
Background	Lymphocyte antigen 6E (LY6E/SCA-2) is a ~13 kDa protein. GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. 1. Zhao, X. et al. (2020) Journal of virology 94. PMID: 32641482
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Anti-Human LY6E/SCA-2 (RG 7841).
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human LY6E/SCA-2 (RG 7841).