Anti-Human MERTK/MER Reference Antibody (RGX-019, RUO) (HC320016)

Name: Anti-Human MERTK/MER Reference Antibody (RGX-019, RUO)
Brand: abinScience
SKU: HC320016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HC320016
Description	Anti-Human MERTK/MER Antibody (RGX-019) (HC320016) is a research-grade recombinant antibody targeting Receptor tyrosine kinase MerTK. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	RGX-019
Expression system	Mammalian cells
Target	Receptor tyrosine kinase MerTK, Proto-oncogene c-Mer, Tyrosine-protein kinase Mer, MERTK, MER
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q12866
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	RGX-019, RGX019, RGX019
Background	Tyrosine-protein kinase Mer (MERTK) is a ~110 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. 1. Moon, B. et al. (2020) Cells 9. PMID: 32640697
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human MERTK/MER Antibody (RGX-019)

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Anti-Human MERTK/MER Reference Antibody (RGX-019, RUO).pdf

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Anti-Human MERTK/MER Reference Antibody (RGX-019, RUO) (HC320016)

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