Anti-Human PLA2G1B Reference Antibody (DIACC 1010, RUO) (HY504016)

Name: Anti-Human PLA2G1B Reference Antibody (DIACC 1010, RUO)
Brand: abinScience
SKU: HY504016
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HY504016
Description	Anti-Human PLA2G1B/PLA2 (DIACC 1010) (HY504016) is a research-grade recombinant antibody targeting Phospholipase A2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG
Clone ID	DIACC 1010
Expression system	Mammalian cells
Target	Phospholipase A2, PLA2G1B, Group IB phospholipase A2, PLA2A, PPLA2, Phosphatidylcholine 2-acylhydrolase 1B, PLA2
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P04054
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DIACC-1010, DIACC1010, DIACC1010
Background	Phospholipase A2 (PLA2G1B/PLA2) is a ~16 kDa protein. Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner. 1. Suzuki, N. et al. (2000) The Journal of biological chemistry 275, 5785-93. PMID: 10681567 2. Kanda, A. et al. (1992) Biochimica et biophysica acta 1171, 1-10. PMID: 1420353 3. Yu, BZ. et al. (2007) Biochimica et biophysica acta 1768, 2478-90. PMID: 17603006 4. Pan, Y. et al. (2014) Scientific reports 4, 6660. PMID: 25335547 5. Ancian, P. et al. (1995) The Journal of biological chemistry 270, 8963-70. PMID: 7721806
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human PLA2G1B/PLA2 (DIACC 1010)

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Datasheet

Anti-Human PLA2G1B Reference Antibody (DIACC 1010, RUO).pdf

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Anti-Human PLA2G1B Reference Antibody (DIACC 1010, RUO) (HY504016)

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