Anti-Human TWEAK/TNFSF12 Reference Antibody (BIIB023, RUO) (HT065016)

Name: Anti-Human TWEAK/TNFSF12 Reference Antibody (BIIB023, RUO)
Brand: abinScience
SKU: HT065016
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HT065016
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Clone ID	BIIB023
Expression system	Mammalian cells
Clonality	Monoclonal
Target	TWEAK, DR3LG, TNFSF12, Tumor necrosis factor ligand superfamily member 12, APO3L, TNF-related weak inducer of apoptosis, APO3 ligand
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O43508
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BIIB023, DHK29401
Background	Tumor necrosis factor ligand superfamily member 12 (CD255/TNFSF12) is a ~27 kDa protein. Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
References	1. Galluppi GR, et al. Population pharmacokinetic and pharmacodynamic analysis of BIIB023, an anti-TNF-like weak inducer of apoptosis (anti-TWEAK) monoclonal antibody. Br J Clin Pharmacol. 2016 Jul;82(1):118-28. [HT065016]
Note	For research use only. Not suitable for clinical or therapeutic use.