Anti-Human TYRO3/DTK/SYK Reference Antibody (ELB031, RUO) (HC368016)

Name: Anti-Human TYRO3/DTK/SYK Reference Antibody (ELB031, RUO)
Brand: abinScience
SKU: HC368016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HC368016
Description	Anti-Human TYRO3/DTK/SYK Antibody (ELB031) (HC368016) is a research-grade recombinant antibody targeting RSE. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	ELB031
Expression system	Mammalian cells
Target	RSE, TYRO3, Tyrosine-protein kinase TIF, Tyrosine-protein kinase RSE, BYK, Tyrosine-protein kinase BYK, DTK, TIF, Tyrosine-protein kinase DTK, SKY, Tyrosine-protein kinase SKY, Tyrosine-protein kinase receptor TYRO3
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q06418
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ELB031, ELB031, ELB-031
Background	Tyrosine-protein kinase receptor TYRO3 (DTK/SYK) is a ~96 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes.
Note	For research use only. Not suitable for clinical or therapeutic use.