Anti-HRSV Post-Fusion Glycoprotein Reference Antibody (ADI-14359, RUO) (VK421116)

Name: Anti-HRSV Post-Fusion Glycoprotein Reference Antibody (ADI-14359, RUO)
Brand: abinScience
SKU: VK421116
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	VK421116
Species reactivity	Human respiratory syncytial virus A (HRSV-A)
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1, kappa
Clone ID	ADI-14359
Biological activity	ADI-14359 binds to epitope I of RSV postF via convergent CDR H3 motifs and germline-encoded features of its IGKV1-39 light chain and IGHV2-70 heavy chain, with key interactions mediated by specific hydrogen bonds and electrostatic contacts [1]. ADI-14359 (6.25 nM-1600 nM) binds to RSV postF with a K D value of 387 nM; the heavy chain Arg50 residue and postF Lys390 residue are critical for this interaction, as disruption of these residues significantly reduces or even completely abolishes binding [1]. ADI-14359 recognizes antigenic epitope I on RSV F, preferentially binds to the post-fusion conformation, and does not neutralize RSV [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	F, Fusion glycoprotein F0, Fusion glycoprotein F2, p27, Intervening segment, Pep27, Peptide 27, Fusion glycoprotein F1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P03420
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ADI-14359
Background	Fusion glycoprotein F0 is a ~63 kDa protein. Inactive precursor that is cleaved at two sites by a furin-like protease to give rise to the mature F1 and F2 fusion glycoproteins.
References	1. Goodwin E, et al. Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity. 2018;48(2):339-349.e5. [VK421116]
Note	For research use only. Not suitable for clinical or therapeutic use.