Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO) (HW651016)

Name: Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO)
Brand: abinScience
SKU: HW651016
Price: 176 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HW651016

Description

Ascrinvacumab (HW651016) is a research-grade recombinant antibody targeting Serine/threonine-protein kinase receptor R3. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Species reactivity

Human

Applications

ELISA, WB, Bioactivity: FACS, Functional assay, Research in vivo

Host species

Human

Isotype

IgG2-kappa

Expression system

Mammalian cells

Clonality

Monoclonal

Tested applications

Target

Serine/threonine-protein kinase receptor R3, ACVRL1, Activin receptor-like kinase 1, ALK-1, ACVRLK1, ALK1, SKR3, TGF-B superfamily receptor type I, TSR-I

Endotoxin level

< 10 EU/mg

Purity

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P37023

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

PF-03446962, 1463459-96-2

Background

Activin receptor type-1-like (ACVRL1/ALK-1) is a ~56 kDa protein. Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Note

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107)

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Ascrinvacumab.
Bioactivity

Detects ACVRL1/ALK-1 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO)
Western blot

Western blot analysis was performed using anti-ACVRL1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human ACVRL1 (Catalog No: HW651011)
Lane 2: negative control