Research Grade Bezeotermin alfa (HB857016)

Name: Research Grade Bezeotermin alfa
Brand: abinScience
SKU: HB857016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HB857016
Description	bezeotermin alfa (HB857016) is a research-grade recombinant antibody targeting bone morphogenetic protein 6/BMP6. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Expression system	Mammalian cells
Nature	Recombinant
Target	bone morphogenetic protein 6/BMP6
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Accession	P22004
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2935496-94-7
Background	Bone morphogenetic protein 6 (BMP6) is a ~57 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. 1. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025 2. Daher, R. et al. (2016) Gastroenterology 150, 672-683.e4. PMID: 26582087 3. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509 4. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 5. Saremba, S. et al. (2008) The FEBS journal 275, 172-83. PMID: 18070108 6. Pulkkinen, HH. et al. (2021) Angiogenesis 24, 129-144. PMID: 33021694
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Research Grade Bezeotermin alfa.pdf

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Research Grade Bezeotermin alfa (HB857016)

Overview

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References

Datasheet

SDS