Anti-Human Fibrinogen beta chain Reference Antibody (Biciromab, RUO) (HF822016)

Name: Anti-Human Fibrinogen beta chain Reference Antibody (Biciromab, RUO)
Brand: abinScience
SKU: HF822016
Price: 176 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HF822016

Description

Biciromab (HF822016) is a research-grade recombinant antibody targeting FGB. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Species reactivity

Human

Applications

ELISA, WB, Bioactivity: FACS, Functional assay, Research in vivo

Host species

Mouse

Isotype

IgG1-kappa

Expression system

Mammalian cells

Clonality

Monoclonal

Target

FGB, Fibrinogen beta chain

Endotoxin level

Please contact the lab for this information.

Purity

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P02675

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

Indium(111In)biciromab, T2G1, 138783-13-8

Background

Fibrinogen beta chain (FGB) is a ~55 kDa protein. Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.

Note

For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

SEC-HPLC detection for Research Grade Biciromab.
SDS-PAGE

SDS-PAGE for Research Grade Biciromab
Western blot

Western blot analysis was performed using anti-FGB monoclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate