Anti-Human Fibronectin & IL-2 Bispecific Reference Antibody (Bifikafusp Alfa, RUO) (HY259056)

Name: Anti-Human Fibronectin & IL-2 Bispecific Reference Antibody (Bifikafusp Alfa, RUO)
Brand: abinScience
SKU: HY259056
Price: 400 USD
Availability: InStock

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Overview

Catalog No.	HY259056
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Isotype	scFv-heavy-kappa
Biological activity	Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury [1]. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans) [2].
Expression system	Mammalian cells
Target	Cold-insoluble globulin, CIG, FN, Fibronectin, FN1, IL2, IL-2, Aldesleukin, Interleukin-2, TCGF, T-cell growth factor
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Purified by Nickel column.
Accession	P02751 & P60568
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	L19-IL-2, L19-IL2, L19IL2, 1957239-90-5
Background	Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity.
References	1. Yuan-Wan Sun, et al. Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice. Chem Res Toxicol. 2021 Apr 19;34(4):1161-1168. [HY259056] 2. Roumen Pankov, et al. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3. [HY259056]
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Anti-Human Fibronectin & IL-2 Bispecific Reference Antibody (Bifikafusp Alfa, RUO).pdf

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Anti-Human Fibronectin & IL-2 Bispecific Reference Antibody (Bifikafusp Alfa, RUO) (HY259056)

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