Anti-Human IL-27 Reference Antibody (Casdozokitug, RUO) (HV969016)

Name: Anti-Human IL-27 Reference Antibody (Casdozokitug, RUO)
Brand: abinScience
SKU: HV969016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HV969016
Description	Casdozokitug (HV969016) is a research-grade recombinant antibody targeting p28. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	p28, Interleukin-27 subunit alpha, IL-27 subunit alpha, IL27A, IL27, IL-27-A, Interleukin-30, IL30, IL27-A
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q8NEV9
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2643331-37-5
Background	Interleukin-27 subunit alpha (IL27A/IL30) is a ~27 kDa protein. Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Casdozokitug

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Datasheet

Anti-Human IL-27 Reference Antibody (Casdozokitug, RUO).pdf

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Anti-Human IL-27 Reference Antibody (Casdozokitug, RUO) (HV969016)

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Datasheet

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