Anti-Human 4-1BB/TNFRSF9/CD137& HER2 Bispecific Reference Antibody (Cinrebafusp Alfa, RUO) (HC336186)

Name: Anti-Human 4-1BB/TNFRSF9/CD137& HER2 Bispecific Reference Antibody (Cinrebafusp Alfa, RUO)
Brand: abinScience
SKU: HC336186
Price: 176 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HC336186

Description

Cinrebafusp alfa (HC336186) is a research-grade recombinant antibody targeting CD137. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Species reactivity

Human

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo, WB

Host species

Human

Isotype

IgG

Expression system

Mammalian cells

Tested applications

Target

Bispecific, Tumor necrosis factor receptor superfamily member 9, CD137, 4-1BB ligand receptor, CDw137, TNFRSF9, T-cell antigen ILA, T-cell antigen 4-1BB homolog, ILA, p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein

Endotoxin level

Please contact the lab for this information.

Purity

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q07011 & P04626

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.

Note

For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Cinrebafusp alfa.
Bioactivity

Detects recombinant CD340 (Catalog No: HY286011) in indirect ELISA.
Bioactivity

Detects recombinant CD137 (Catalog No: HC336011) in indirect ELISA.
Western blot

Western blot analysis was performed using anti-CD137 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD137 (Catalog No: HC336011)
Lane 2: Negative control

References

Datasheet

Anti-Human 4-1BB/TNFRSF9/CD137& HER2 Bispecific Reference Antibody (Cinrebafusp Alfa, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human 4-1BB/TNFRSF9/CD137& HER2 Bispecific Reference Antibody (Cinrebafusp Alfa, RUO) (HC336186)

Overview

Images

References

Datasheet

SDS

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