Research Grade Clazakizumab (HY328056)

Datasheet Share product Copy info

Price(USD): $

Spec:

100ug
1mg

Number:

Overview
Images
References
Datasheet

Overview

Catalog No.	HY328056
Description	Research Grade Clazakizumab (HY328056) is a humanized monoclonal antibody detecting Hybridoma growth factor in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Species	Human
Clonality	Monoclonal
Target	Hybridoma growth factor, BSF-2, IFN-beta-2, CDF, IL6, Interleukin-6, IL-6, B-cell stimulatory factor 2, Interferon beta-2, IFNB2, CTL differentiation factor
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P05231
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternate Names	ALD-518, BMS-945429, 1236278-28-6
Background	Interleukin-6 (Hybridoma growth factor,BSF-2,IFN-beta-2,CDF,IL6,Interleukin-6,IL-6,B-cell stimulatory factor 2,Interferon beta-2,IFNB2,CTL differentiation factor) is a ~23 kDa protein. Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Clazakizumab.
Bioactivity

Detects Human IL6 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Clazakizumab
Western blot

Western blot analysis was performed using anti-IL6 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL6 (Catalog No: HY328021)
Lane 2: negative control