Anti-Human PTK7/CCK-4 Reference Antibody (Cofetuzumab, RUO) (HC437016)

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100ug
1mg

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Overview

Catalog No.	HC437016
Description	Cofetuzumab (HC437016) is a research-grade recombinant antibody targeting Protein-tyrosine kinase 7. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Protein-tyrosine kinase 7, Inactive tyrosine-protein kinase 7, CCK4, PTK7, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7, CCK-4, Pseudo tyrosine kinase receptor 7
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q13308
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	PF-06523435, hu24, Anti-PTK7ADC, PF-06647020, PTK7-ADC, 1869928-62-0
Background	Inactive tyrosine-protein kinase 7 (PTK7/CCK-4) is a ~118 kDa protein. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects Human PTK7/CCK-4 in indirect ELISAs.
Bioactivity

SEC-HPLC detection for Research Grade Cofetuzumab.
SDS-PAGE

SDS-PAGE for Research Grade Cofetuzumab.

References

Datasheet

Anti-Human PTK7/CCK-4 Reference Antibody (Cofetuzumab, RUO).pdf

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Recombinant Proteins

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Anti-Human PTK7/CCK-4 Reference Antibody (Cofetuzumab, RUO) (HC437016)

Overview

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References

Datasheet

SDS

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