Research Grade corabotase (JN888016)

Name: Research Grade corabotase
Brand: abinScience
SKU: JN888016
Price: 370 USD
Availability: InStock

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SDS

Overview

Catalog No.	JN888016
Description	corabotase (JN888016) is a research-grade recombinant antibody targeting BoNT/A/botA & BoNT/B/botB. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Clostridium botulinum
Applications	ELISA, Functional assay, Research in vivo
Clonality	Monoclonal
Expression system	Mammalian cells
Nature	Recombinant
Target	BoNT/A/botA & BoNT/B/botB
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Accession	P0DPI1 & B1INP5
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2616765-46-7
Background	Botulinum neurotoxin type A (botA/BOTOX) is a ~149 kDa protein. Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin A which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins of synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. 1. Blasi, J. et al. (1993) Nature 365, 160-3. PMID: 8103915 2. Fu, Z. et al. (2009) Biochemistry 48, 5631-41. PMID: 19476346
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade corabotase

References

Datasheet

Research Grade corabotase.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

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g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

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Working Solution

C₂ (Working Conc.)

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Recombinant Proteins

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Research Grade corabotase (JN888016)

Overview

Images

References

Datasheet

SDS