Anti-Human CCL17/TARC Reference Antibody (Denrakibart, RUO) (HV615016)

Name: Anti-Human CCL17/TARC Reference Antibody (Denrakibart, RUO)
Brand: abinScience
SKU: HV615016
Price: 176 USD
Availability: InStock

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SDS

Overview

Catalog No.	HV615016
Description	denrakibart (HV615016) is a research-grade recombinant antibody targeting CCL17/TARC. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG2, Kappa
Expression system	Mammalian cells
Nature	Recombinant
Target	CCL17/TARC
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Accession	Q92583
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2922866-66-6
Background	C-C motif chemokine 17 (CCL17/TARC) is a ~10 kDa protein. Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. 1. Imai, T. et al. (1996) The Journal of biological chemistry 271, 21514-21. PMID: 8702936 2. Imai, T. et al. (1997) The Journal of biological chemistry 272, 15036-42. PMID: 9169480 3. Garlisi, CG. et al. (1999) European journal of immunology 29, 3210-5. PMID: 10540332 4. Achuthan, A. et al. (2016) The Journal of clinical investigation 126, 3453-66. PMID: 27525438
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade denrakibart

References

Datasheet

Anti-Human CCL17/TARC Reference Antibody (Denrakibart, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

C₁ × V₁ = C₂ × V₂

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Recombinant Proteins

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Anti-Human CCL17/TARC Reference Antibody (Denrakibart, RUO) (HV615016)

Overview

Images

References

Datasheet

SDS