Anti-Human Sialidase-2 Reference Antibody (Efgitasialase Alfa, RUO) (HA532016)

Name: Anti-Human Sialidase-2 Reference Antibody (Efgitasialase Alfa, RUO)
Brand: abinScience
SKU: HA532016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HA532016
Description	efgitasialase alfa (HA532016) is a research-grade recombinant antibody targeting sialidase-2. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Clonality	Monoclonal
Expression system	Mammalian cells
Nature	Recombinant
Target	sialidase-2
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Accession	Q9Y3R4
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2891502-37-5
Background	Sialidase-2 is a ~42 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. 1. Tringali, C. et al. (2004) The Journal of biological chemistry 279, 3169-79. PMID: 14613940 2. Mozzi, A. et al. (2012) Proteins 80, 1123-32. PMID: 22228546
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Anti-Human Sialidase-2 Reference Antibody (Efgitasialase Alfa, RUO).pdf

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Formula

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Recombinant Proteins

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Anti-Human Sialidase-2 Reference Antibody (Efgitasialase Alfa, RUO) (HA532016)

Overview

Images

References

Datasheet

SDS