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Anti-Human CD117/c-kit Reference Antibody (Eglatoprutug, RUO) (HY163036)

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Anti-Human CD117/c-kit Reference Antibody (Eglatoprutug, RUO)

Anti-Human CD117/c-kit Reference Antibody (Eglatoprutug, RUO)

Anti-Human CD117/c-kit Reference Antibody (Eglatoprutug, RUO)

Anti-Human CD117/c-kit Reference Antibody (Eglatoprutug, RUO)

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Spec:

100ug
1mg

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Datasheet
SDS

Overview

Catalog No.	HY163036
Description	Eglatoprutug (HY163036) is a research-grade recombinant antibody targeting CD117. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Mast/stem cell growth factor receptor Kit, p145 c-kit, Tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, KIT, PBT, Piebald trait protein, Proto-oncogene c-Kit, SCFR, CD117
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P10721
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2518200-21-8
Background	Mast/stem cell growth factor receptor Kit (CD117) is a ~109 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Eglatoprutug.
Bioactivity

Detects recombinant CD117 (Catalog No: HY163011) in indirect ELISA.

References

Datasheet

Anti-Human CD117/c-kit Reference Antibody (Eglatoprutug, RUO).pdf

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Anti-Human CD117/c-kit Reference Antibody (Eglatoprutug, RUO)