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Anti-Human PD-L1 & CTLA-4 Bispecific Reference Antibody (Erfonrilimab, RUO) (HV974146)

Anti-Human PD-L1 & CTLA-4 Bispecific Reference Antibody (Erfonrilimab, RUO)
Anti-Human PD-L1 & CTLA-4 Bispecific Reference Antibody (Erfonrilimab, RUO)
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Overview
Catalog No.HV974146
Description
Erfonrilimab (HV974146) is a research-grade recombinant antibody targeting CD152. Produced in mammalian cells with native-like glycosylation.
Highlights
  • Research Grade — For PK/PD studies, assay development, and ADA research.
  • Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivityHuman
ApplicationsELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host speciesHuman
ClonalityMonoclonal
IsotypeSingle Domains (VH-VH'-CH), IgG1na;na
Target B7 homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1, CD152, CTLA-4, CTLA4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Endotoxin level < 10 EU/mg
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession Q9NZQ7 & P16410
Form Liquid
Storage buffer 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate NamesBispecific, KN-046, KN046, 2367013-69-0
BackgroundErfonrilimab (KN-046) is an anti-PDL1/CTLA-4 monoclonal antibody.
Note For research use only. Not suitable for clinical or therapeutic use.
Images
  • Anti-Human PD-L1 & CTLA-4 Bispecific Reference Antibody (Erfonrilimab, RUO)

    Bioactivity

    Detects CD274/PD-L1/B7-H1 in indirect ELISAs.

References
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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