Anti-Human CD4 Reference Antibody (Ibalizumab, RUO) (HF998016)

Name: Anti-Human CD4 Reference Antibody (Ibalizumab, RUO)
Brand: abinScience
SKU: HF998016
Price: 320 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HF998016
Description	Ibalizumab (HF998016) is a research-grade recombinant antibody targeting CD4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, CD4
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P01730
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Hu5A8, TMB-355, TNX-355, 680188-33-4
Background	T-cell surface glycoprotein CD4 is a ~51 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Ibalizumab.
Bioactivity

Detects Human CD4 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Ibalizumab
Western blot

Western blot analysis was performed using anti-CD4 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human CD4 (Catalog No: HF998011), 30ng
Lane 2: recombinant human CD4 (Catalog No: HF998011), 20ng
Lane 3: recombinant human CD4 (Catalog No: HF998011), 10ng