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Anti-Human SIRP alpha/CD172a Reference Antibody (Ipsoprubart, RUO) (HX892146)

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Anti-Human SIRP alpha/CD172a Reference Antibody (Ipsoprubart, RUO)

Anti-Human SIRP alpha/CD172a Reference Antibody (Ipsoprubart, RUO)

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Spec:

100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HX892146
Description	ipsoprubart (HX892146) is a research-grade recombinant antibody targeting CD172. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, FACS, Functional assay
Host species	Human
Isotype	IgG1, kappa
Target	CD172a/SIRPA
Purity	>95% as determined by SDS-PAGE
Accession	P78324
Storage buffer	0.01 M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CAS: 3035552-25-8
Background	Tyrosine-protein phosphatase non-receptor type substrate 1 is a ~54 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. 1. Yao, M. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 1171-86. PMID: 24511121
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Research Grade ipsoprubart

References

Datasheet

Anti-Human SIRP alpha/CD172a Reference Antibody (Ipsoprubart, RUO).pdf

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Formula

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Working Solution

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Anti-Human SIRP alpha/CD172a Reference Antibody (Ipsoprubart, RUO)