Anti-Human CD6 Reference Antibody (Itolizumab, RUO) (HB797016)

Name: Anti-Human CD6 Reference Antibody (Itolizumab, RUO)
Brand: abinScience
SKU: HB797016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HB797016
Description	Research Grade Itolizumab (HB797016) is a humanized monoclonal antibody detecting TP120 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Species	Human
Clonality	Monoclonal
Target	TP120, CD6, T12, T-cell differentiation antigen CD6
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P30203
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	T1h, 1116433-11-4
Background	T-cell differentiation antigen CD6 (TP120,CD6,T12,T-cell differentiation antigen CD6) is a ~71 kDa protein. Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. 1. Hassan, NJ. et al. (2004) European journal of immunology 34, 930-40. PMID: 15048703 2. Gimferrer, I. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 2262-70. PMID: 15294938 3. Zimmerman, AW. et al. (2006) Blood 107, 3212-20. PMID: 16352806 4. Hassan, NJ. et al. (2006) Molecular and cellular biology 26, 6727-38. PMID: 16914752 5. Roncagalli, R. et al. (2014) Nature immunology 15, 384-392. PMID: 24584089 6. Escoda-Ferran, C. et al. (2014) FEBS letters 588, 2805-13. PMID: 24945728
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects CD6 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Itolizumab.

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Datasheet

Anti-Human CD6 Reference Antibody (Itolizumab, RUO).pdf

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Anti-Human CD6 Reference Antibody (Itolizumab, RUO) (HB797016)

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