Anti-Human FOLR1 Reference Antibody (Lazatatug, RUO) (HB825076)

Name: Anti-Human FOLR1 Reference Antibody (Lazatatug, RUO)
Brand: abinScience
SKU: HB825076
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HB825076
Description	lazatatug (HB825076) is a research-grade recombinant antibody targeting FOLR1. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, FACS, Functional assay
Host species	Human
Isotype	IgE, kappa
Target	FOLR1
Purity	>95% as determined by SDS-PAGE
Accession	P15328
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CAS: 3035565-36-4
Background	Folate receptor alpha is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. 1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442 2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396 3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049 4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252 5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114 6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728
Note	For research use only.

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Anti-Human FOLR1 Reference Antibody (Lazatatug, RUO).pdf

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Anti-Human FOLR1 Reference Antibody (Lazatatug, RUO) (HB825076)

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