Anti-Human PSCA Reference Antibody (Mk-4721, RUO) (HT361026)

Name: Anti-Human PSCA Reference Antibody (Mk-4721, RUO)
Brand: abinScience
SKU: HT361026
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HT361026
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	scFv-hFc
Biological activity	AGS-1C4D4 displays potent ADCC activity against PSCA-expressing HPAC and Panc0203 pancreatic cell lines, with activity greatly reduced by deglycosylation, and is more potent than the hybridoma-derived AGS-PSCA antibody in this assay [1]. AGS-1C4D4 exhibits CDC activity against PSCA-expressing recombinant B300.19 cells, with activity greatly reduced by deglycosylation, and is equally effective as the hybridoma-derived AGS-PSCA antibody in this assay [1]. AGS-1C4D4 binds to PSCA with a K d of 0.2 nM, displaying similar binding affinity to the hybridoma-derived AGS-PSCA antibody [1]. AGS-1C4D4 significantly inhibits established pancreatic tumor growth and metastasis in orthotopic HPAC xenograft models when combined with Gemcitabine (), and also significantly inhibits pancreatic tumor formation, local invasion, and distant metastasis in the same orthotopic xenograft model [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Prostate stem cell antigen, PSCA
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O43653
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ProscamabA11, MK-4721
Background	Prostate stem cell antigen (PSCA) is a ~11 kDa protein. May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
References	1. Tony Navas, et al. Abstract 4566: AGS-1C4D4: A fully human anti-PSCA antibody inhibits tumor formation and metastasis in orthotopic models of pancreatic cancer. Cancer Res (2011) 71 (8_Supplement): 4566. [HT361026]
Note	For research use only. Not suitable for clinical or therapeutic use.