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Anti-Human Tau Reference Antibody (Moponetug, RUO) (HY086146)

Anti-Human Tau Reference Antibody (Moponetug, RUO)
Anti-Human Tau Reference Antibody (Moponetug, RUO)
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Overview
Catalog No.HY086146
Description
moponetug (HY086146) is a research-grade recombinant antibody targeting MAPT/Tau/PHF-tau.
Highlights
  • Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivityHuman
ApplicationsELISA, FACS, Functional assay
Host speciesHuman
IsotypeIgG1, kappa
Target MAPT/Tau/PHF-tau
Endotoxin level < 10 EU/mg
Purity >95% as determined by SDS-PAGE
Accession P10636
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate NamesCAS: 3031519-40-8
Background

Microtubule-associated protein tau is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76. PMID: 21985311
2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079. PMID: 32961270
Note For research use only.
Images
  • Anti-Human Tau Reference Antibody (Moponetug, RUO)

    SDS-PAGE

    SDS-PAGE for Research Grade moponetug

References
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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