

| Catalog No. | HY086146 |
|---|---|
| Description |
moponetug (HY086146) is a research-grade recombinant antibody targeting MAPT/Tau/PHF-tau.
Highlights
|
| Species reactivity | Human |
| Applications | ELISA, FACS, Functional assay |
| Host species | Human |
| Isotype | IgG1, kappa |
| Target | MAPT/Tau/PHF-tau |
| Endotoxin level | < 10 EU/mg |
| Purity | >95% as determined by SDS-PAGE |
| Accession | P10636 |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternate Names | CAS: 3031519-40-8 |
| Background | Microtubule-associated protein tau is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. 1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76. PMID: 21985311 2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079. PMID: 32961270 |
| Note | For research use only. |

SDS-PAGE for Research Grade moponetug




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