Anti-Human IL-31RA Reference Antibody (Nolavetbart, RUO) (CV121016)

Name: Anti-Human IL-31RA Reference Antibody (Nolavetbart, RUO)
Brand: abinScience
SKU: CV121016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	CV121016
Description	Nolavetbart (CV121016) is a research-grade recombinant antibody targeting IL31RA. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Canine
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Canine
Clonality	Monoclonal
Isotype	IgG2-kappa
Expression system	Mammalian cells
Nature	Recombinant
Target	IL31RA
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	A0A8I3Q391
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2750248-93-0
Background	Interleukin-31 receptor subunit alpha (IL31RA) is a ~82 kDa protein. Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. 1. Ghilardi, N. et al. (2002) The Journal of biological chemistry 277, 16831-6. PMID: 11877449 2. Diveu, C. et al. (2003) The Journal of biological chemistry 278, 49850-9. PMID: 14504285 3. Dreuw, A. et al. (2004) The Journal of biological chemistry 279, 36112-20. PMID: 15194700 4. Diveu, C. et al. (2004) European cytokine network 15, 291-302. PMID: 15627637 5. Dillon, SR. et al. (2004) Nature immunology 5, 752-60. PMID: 15184896
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Anti-Human IL-31RA Reference Antibody (Nolavetbart, RUO).pdf

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Anti-Human IL-31RA Reference Antibody (Nolavetbart, RUO) (CV121016)

Overview

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References

Datasheet

SDS