Anti-Human Fibronectin&TNF-alpha Reference Antibody (Onfekafusp Alfa, RUO) (HP900016)

Name: Anti-Human Fibronectin&TNF-alpha Reference Antibody (Onfekafusp Alfa, RUO)
Brand: abinScience
SKU: HP900016
Price: 424 USD
Availability: InStock

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Overview

Catalog No.	HP900016
Description	Onfekafusp Alfa (HP900016) is a research-grade recombinant antibody targeting EDB. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	[scFv-heavy-kappa-TNF(tumornecrosisfactor(TNF)superfamilymember2, TNFSF2, TNF-alpha, TNFA)]-trimer
Expression system	Mammalian cells
Clonality	Monoclonal
Target	EDB, EDB-FN
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P02751-7
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	L19TNF, L19TNF-alpha, 1957239-88-1
Background	Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research. • EDB-FN targeted probes for the surgical navigation, radionuclide imaging, and therapy of thyroid cancer., PMID:36807768 • EDB-FN Targeted Peptide-Drug Conjugates for Use against Prostate Cancer., PMID:31277465 • EDB-FN-targeted probes for near infrared fluorescent imaging and positron emission tomography imaging of breast cancer in mice., PMID:39333775 • Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade., PMID:35793468 • Evaluation of EDB Fibronectin in Plasma, Patient-Derived Xenograft Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tumor Tissues Using Immunoaffinity LC-MS/MS., PMID:36049057 • EDB Fibronectin-Specific SPECT Probe ^99mTc-HYNIC-ZD2 for Breast Cancer Detection., PMID:30023665 • Tenascin-C: Form versus function., PMID:25482829 • EDB Fibronectin Specific Peptide for Prostate Cancer Targeting., PMID:25848940 • EDB fibronectin and angiogenesis -- a novel mechanistic pathway., PMID:16308732 • RT-PCR detection of fibronectin EDA+ and EDB+ mRNA isoforms: molecular markers for hepatocellular carcinoma., PMID:7509777
Note	For research use only. Not suitable for clinical or therapeutic use.

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Anti-Human Fibronectin&TNF-alpha Reference Antibody (Onfekafusp Alfa, RUO).pdf

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Anti-Human Fibronectin&TNF-alpha Reference Antibody (Onfekafusp Alfa, RUO) (HP900016)

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