Anti-Human ROR2 Reference Antibody (Ozuriftamab, RUO) (HX930016)

Name: Anti-Human ROR2 Reference Antibody (Ozuriftamab, RUO)
Brand: abinScience
SKU: HX930016
Price: 176 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HX930016
Description	Ozuriftamab (HX930016) is a research-grade recombinant antibody targeting ROR2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	ROR2, Neurotrophic tyrosine kinase, receptor-related 2, NTRKR2, Tyrosine-protein kinase transmembrane receptor ROR2
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q01974
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BA302, 2460399-44-2
Background	Tyrosine-protein kinase transmembrane receptor ROR2 (NTRKR2) is a ~104 kDa protein. Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. 1. Liu, Y. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 3050-61. PMID: 17717073 2. Bainbridge, TW. et al. (2014) PloS one 9, e102695. PMID: 25029443
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

Detects Human ROR2/NTRKR2 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Ozuriftamab.
Flow CytoMetry

Flow-cytometry using anti-human ROR2 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human ROR2 monoclonal antibody (Catalog: HX930016) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry APC using anti-human ROR2 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an APC anti-human ROR2 monoclonal antibody (Catalog HX930016) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry PE using anti-human ROR2 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an PE anti-human ROR2 monoclonal antibody (Catalog HX930016) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.