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Anti-Human DPEP3 Reference Antibody (Pintumomab, RUO) (HV426016)

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Anti-Human DPEP3 Reference Antibody (Pintumomab, RUO)

Anti-Human DPEP3 Reference Antibody (Pintumomab, RUO)

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Overview

Catalog No.	HV426016
Description	Pintumomab (HV426016) is a research-grade recombinant antibody targeting DPEP3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Mouse
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	DPEP3, Dipeptidase 3
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9H4B8
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	170, 339177-26-3
Background	Dipeptidase 3 (DPEP3) is a ~53 kDa protein. Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem. The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide. A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance. 1. Hayashi, K. et al. (2020) Journal of structural biology 211, 107512. PMID: 32325220
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Pintumomab

References

Datasheet

Anti-Human DPEP3 Reference Antibody (Pintumomab, RUO).pdf

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Anti-Human DPEP3 Reference Antibody (Pintumomab, RUO)